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Isoniazid should be administered with caution to patients with convulsive disorders, a history of psychosis or hepatic or renal dysfunction. Patients who are at risk of neuropathy or pyridoxine deficiency, including those who are diabetic, alcoholic, malnourished, uremic, pregnant or HIV-infected should receive pyridoxine usually in a dose of 10 mg daily, although some have suggested using up to 50 mg daily. If symptoms of hepatitis eg, malaise, fatigue, anorexia and nausea develop, isoniazid should be discontinued pending evaluation.
Liver function should be checked before treatment with isoniazid and special care should be taken in alcoholic patients or those with preexisting liver disease.
